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- SDK Software Development Kit
- SE&I System Engineering and Integration
- SEWP Solutions for Enterprise-Wide Procurement
- SIGMA Space for International Global Maritime Awareness
- SLA Service Level Agreement
- SLF Shuttle Landing Facility
- SMTP Simple Mail Transport Protocol
- SN Serial Number
- SNMP Simple Network Management Protocol
- SNR Signal to Noise Ratio
- SOAP Simple Object Access Protocol
- SOC Security Operations Center
- SoC System on a Chip
- SOP Standard Operating Procedure
- SOW Statement of Work
- SQL Structured Query Language
- SR&QA Safety, Reliability, and Quality Assurance
- SRAM Static Random Access Memory
- SRB Solid Rocket Booster
- Search for "Security" with